iMED publications

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  1. 2024
  2. Published

    Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

    Metrangolo, Virginia & Engelholm, Lars Henning, 2024, In: Cancers. 16, 2, 20 p., 447.

    Research output: Contribution to journal › Review › Research › peer-review

  3. 2023
  4. Published

    ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

    Piotrowski, Kris, Puig Blasco, Laia, Samsøe-Petersen, Jacob, Eefsen, R. L., Illemann, M., Oria, Victor Oginga, Campos, K. I. A., Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, X. F., Kveiborg, Marie & Gnosa, S., 2023, In: Cancer Gene Therapy. 30, p. 1369-1381 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

    Anichini, G., Raggi, C., Pastore, M., Carrassa, L., Maresca, L., Crivaro, E., Lottini, T., Duwe, Lea, Andersen, Jesper Bøje, Tofani, L., Di Tommaso, L., Banales, J. M., Arcangeli, A., Marra, F. & Stecca, B., 2023, In: Molecular Cancer Therapeutics. 22, 3, p. 343-356 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

    Nitschke, N. J., Almosailleakh, M., Niu, Yiyuan, Hansen, Jakob Werner, Raaschou-Jensen, K., Jespersen, Jakob Schmidt, Severinsen, M. T., Roug, A. S., Frödin, Morten, Weischenfeldt, Joachim Lütken, Andersen, M. K. & Grønbæk, Kirsten, 2023, In: Human Mutation. 2023, 11 p., 4738660.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

    Kumari, Anni, Grønnemose, A. L., Kristensen, Kristian Kølby, Winther, Anne-Marie Lund, Young, S. G., Jørgensen, T. J. D. & Ploug, Michael, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 18, e2221888120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

    Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

    Puig Blasco, Laia, Piotrowski, Kris, Michaelsen, Signe Regner, Bager, Nicolai Stilling Schou, Areškevičiūtiė, A., Thorseth, M., Sun, X., Keller, U. A. D., Kristensen, Bjarne Winther, Madsen, D. H., Gnosa, S. P. & Kveiborg, Marie, 2023, In: International Journal of Cancer. 153, 12, p. 2068–2081 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model

    Almosailleakh, M., Bentivegna, Sofia, Narcisi, S., Benquet, Sébastien Jean, Gillberg, Linn, Montaño-Almendras, C. P., Savickas, S., Schoof, E. M., Wegener, A., Luche, H., Jensen, Henrik Elvang, Côme, Christophe Roger Michel & Grønbæk, Kirsten, 2023, In: Genes. 14, 10, 1947.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

    Duwe, Lea, Munoz-Garrido, P., Lewinska, Monika, Lafuente Barquero, Juan Francisco, Satriano, L., Høgdall, Dan Taksony Solyom, Taranta, A., Nielsen, B. S., Ghazal, A., Matter, M. S., Banales, J. M., Aldana, Blanca, Gao, Y., Marquardt, J. U., Roberts, L. R., Oliveira, R. C., Koshiol, J., O'Rourke, Colm & Andersen, Jesper Bøje, 2023, In: Journal of Hepatology. 78, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

    Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H., 2023, In: Developmental Cell. 58, 17, p. 1593-1609.e9

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

    Grier, K. E., Hansen, A. H., Haxvig, C. S., Li, Xin, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning, Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N. & Qvortrup, K. M., 2023, In: Chemical Communications. 59, 47, p. 7240-7242

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

    Trempenau, M. L., Schuster, Mikkel Bruhn, Pundhir, Sachin, Araújo Pereira, Mafalda, Kalvisa, A., Tapia, Marta Cecylia, Su, Jinyu, Ge, Y., de Boer, Bauke, Balhuizen, Alexander, Bagger, F. O., Shliaha, P., Sroczynska, P., Walfridsson, J., Grønbæk, Kirsten, Theilgaard-Mønch, Kim, Jensen, O. N., Helin, K. & Porse, Bo Torben, 2023, In: Leukemia. 37, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

    Pikkupeura, Laura Maarit, Bardini Bressan, Raul, Guiu, J., Chen, Y., Maimets, Martti, Mayer, Daniela, Schweiger, P. J., Hansen, Stine Lind, Maciag, Grzegorz Jerzy, Larsen, Hjalte List, Lõhmussaar, Kadi, Pedersen, M. T., Teves, Joji Marie Yap, Lange, Jette Bornholdt, Benes, V., Sandelin, Albin Gustav & Jensen, Kim Bak, 2023, In: Science Advances. 9, 28, 16 p., eadf9460.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2022
  17. Published

    ADAM17-mediated EGFR ligand shedding directs macrophage promoted cancer cell invasion

    Gnosa, S., Puig Blasco, Laia, Piotrowski, Kris, Freiberg, M. L., Savickas, S., Madsen, Daniel Hargbøl, Keller, U. A. D., Kronqvist, P. & Kveiborg, Marie, 2022, In: JCI insight. 7, 18, 21 p., e155296.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Inhibition of oxidized nucleotide sanitation by TH1579 and conventional chemotherapy cooperatively enhance oxidative DNA-damage and survival in AML

    Centio, A., Estruch Alrich, Montserrat, Reckzeh, K., Sanjiv, K., Vittori, Camilla, Engelhard, Sophia Manon Charlotte, Warpman Berglund, U., Helleday, T. & Theilgaard-Mønch, Kim, 2022, In: Molecular Cancer Therapeutics. p. 703-714

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Lipid alterations in chronic liver disease and liver cancer

    Paul, Bichitra, Lewinska, Monika & Andersen, Jesper Bøje, 2022, In: JHEP Reports. 4, 6, 18 p., 100479.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

    Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Therapeutic Potential of an Immune-Modulatory Vaccination Targeting Myeloid-Derived Suppressor Cells in Myelodysplastic Syndrome

    Bentivegna, Sofia, Holmstrøm, M., Balhuizen, Alexander, Almosailleakh, M., Perez Penco, Maria, Porse, Bo Torben, Andersen, Mads Hald & Grønbæk, Kirsten, 2022, In: Blood. 140, Suppl. 1, p. 4007-4008 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  22. Published

    Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

    Duwe, Lea, Fouassier, L., Lafuente Barquero, Juan Francisco & Andersen, Jesper Bøje, 2022, In: Translational Oncology. 26, 13 p., 101531.

    Research output: Contribution to journal › Review › Research › peer-review

  23. 2021
  24. Published

    ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

    Winther, Anne-Marie Lund, Kumari, Anni, Young, S. G. & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 2 p., 100071.

    Research output: Contribution to journal › Comment/debate › Research

  25. Published

    Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

    Tóth, M., Wehling, L., Thiess, L., Rose, F., Schmitt, J., Weiler, S. M. E., Sticht, C., De La Torre, C., Rausch, M., Albrecht, T., Grabe, N., Duwe, L., Andersen, J. B., Köhler, B. C., Springfeld, C., Mehrabi, A., Kulu, Y., Schirmacher, P., Roessler, S., Goeppert, B. & 1 others, Breuhahn, K., 2021, In: BMC Cancer. 21, 1, 14 p., 1079.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

    Gentilini, A., Lori, G., Caligiuri, A., Raggi, C., Di Maira, G., Pastore, M., Piombanti, B., Lottini, T., Arcangeli, A., Madiai, S., Navari, N., Banales, J. M., Di Matteo, S., Alvaro, D., Duwe, L., Andersen, J. B., Tubita, A., Tusa, I., Di Tommaso, L., Campani, C. & 2 others, Rovida, E. & Marra, F., 2021, In: Hepatology. 74, 4, p. 2007-2020

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

    Kristensen, Kristian Kølby, Leth-Espensen, K. Z., Kumari, Anni, Grønnemose, A. L., Winther, Anne-Marie Lund, Young, S. G. & Ploug, Michael, 2021, In: Frontiers in Cell and Developmental Biology. 9, 20 p., 702508.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Regulation of translation by site-specific ribosomal RNA methylation

    Jansson, Martin David, Häfner, Sophia Julia, Altinel, Kübra, Tehler, D. E., Krogh, Nicolai, Jakobsen, Emil, Andersen, Jens Velde, Andersen, Kasper Langebjerg, Schoof, E., Ménard, Patrice, Nielsen, Henrik & Lund, Anders H., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 889-899

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy

    Estruch Alrich, Montserrat, Reckzeh, K., Vittori, Camilla, Centio, A., Ali, M., Engelhard, Sophia Manon Charlotte, Zhao, L., Won, K. J., Liu, P., Porse, Bo Torben & Theilgaard-Mønch, Kim, 2021, In: Leukemia. 35, p. 2030-2042

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target

    Cakilkaya, Pinar, Sørensen, R. R., Jürgensen, Henrik Jessen, Krigslund, O., Gårdsvoll, Henrik, Nielsen, C. F., Santoni Rugiu, Eric, Behrendt, Niels & Engelholm, Lars Henning, 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The Importance of Lipoprotein Lipase Regulation in Atherosclerosis

    Kumari, Anni, Kristensen, Kristian Kølby, Ploug, Michael & Winther, Anne-Marie Lund, 2021, In: Biomedicines. 9, 7, 24 p., 782.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

    Metrangolo, Virginia, Ploug, Michael & Engelholm, Lars Henning, 2021, In: Cancers. 13, 21, 45 p., 5376.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

    Leth-Espensen, K. Z., Kristensen, Kristian Kølby, Kumari, Anni, Winther, Anne-Marie Lund, Young, S. G., Jørgensen, T. J. D. & Ploug, Michael, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 12, e2026650118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2020
  35. Published

    INDEL detection, the 'Achilles heel' of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

    Bennett, Eric Paul, Petersen, B. L., Johansen, I. E., Niu, Yiyuan, Yang, Zhang, Chamberlain, C. A., Met, Özcan, Wandall, Hans H. & Frödin, Morten, 2020, In: Nucleic Acids Research. 48, 21, p. 11958-11981 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Mapping Cellular Coordinates through Advances in Spatial Transcriptomics Technology

    Teves, Joji Marie Yap & Won, K. J., 2020, In: Molecules and Cells. 43, 7, p. 591-599 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  37. 2019
  38. Published

    Evolution and Medical Significance of LU Domain-Containing Proteins

    Leth, Julie Maja, Leth-Espensen, K. Z., Kristensen, Kristian Kølby, Kumari, Anni, Winther, Anne-Marie Lund, Young, S. G. & Ploug, Michael, 2019, In: International Journal of Molecular Sciences. 20, 11, p. 1-20 20 p.

    Research output: Contribution to journal › Review › Research › peer-review